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These percentages are similar to those we found in a previous study of patients who received neither prophylaxis nor placebo against delayed emesis, in which the same regimen for prophylaxis against emesis during the first 24 hours was used.

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The oral form of ondansetron could provide satisfactory rescue for breakthrough delayed emesis when compared to the Intramuscular form of ondansetron, with a similar adverse event profile.

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Davis PJ, McGowan FX Jr, Landsman I, Maloney K, Hoffmann P: Effect of antiemetic therapy on recovery and hospital discharge time.

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Relatively little research has examined the role of antiemetic agents in the treatment of acute gastroenteritis.

Patients were randomly allocated to one of two treatment groups for rescue antiemetic treatment: intramuscular ondansetron 8 mg or oral ondansetron 16 mg for days two to six (antiemetic prophylaxis was provided by ondansetron 8 mg IV plus dexamethasone 8 mg IV for acute emesis and dexamethasone 8 mg for four days for delayed emesis).

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Having smaller amounts of food and fluids more often can help prevent mild cases of nausea and vomiting from worsening.

These researchers included records published (full-length articles after 1997 and conference presentations after 2010) in English and with human patients, reporting data on cost and utilization (rescue medication, outpatient and inpatient services) associated with the use of 5-HT3RAs for the treatment or prevention of CINV.

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Relative risks and 95 percent confidence intervals are presented for all results.


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Approval from the University of Michigan Institutional Review Board (IRB) and written informed consent from a parent or legal guardian was obtained for this prospective, observational, historically controlled study.

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Tropisetron plus dexamethasone is more effective than tropisetron alone for the prevention of postoperative nausea and vomiting in children undergoing tonsillectomy.

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Continued development of new treatments is necessary.

The impact of 5-HT3RA use on cost and utilization in patients with chemotherapy-induced nausea and vomiting: Systematic review of the literature.

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They stated that the use of palonosetron as a standard treatment may lead to reduced service utilization for CINV.

Rather, their sedative, anxiolytic, and amnesic properties may enhance the effectiveness of other antiemetic regimens and they may prevent the development of anticipatory emesis.

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The serotonin then stimulates the vagal and splanchnic nerve receptors that project to the medullary vomiting center, as well as the 5-HT 3 receptors in the area postrema, thus initiating the vomiting reflex, causing nausea and vomiting.

They should not be used before 12 to 14 weeks of gestation due to possible detrimental effects to the developing fetus.

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Viale PH, Grande C, Moore S: Efficacy and cost: avoiding undertreatment of chemotherapy-induced nausea and vomiting.

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Prediction of risk and mortality is difficult, but measures can be undertaken to help determine if patients are at risk for either intraoperative or postoperative complications.

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After 8 days of culture in differentiation medium, Ucp1 expression was upregulated in Tph1-null brown adipocytes, which was abrogated by 5-HT treatment ().

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Randomized double-blind study of the Reliefband as an adjunct to standard antiemetics in patients receiving moderately-high to highly emetogenic chemotherapy.

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Patients received the first dose of ondansetron tablets (8 mg) or metoclopramide (10 mg) 1 to 2 hours before radiotherapy.

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Studies were extracted if they included complete response (CR), complete control (CC), no nausea, no vomiting, and no rescue medications as an end-point.

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Individual IV doses should not exceed 16 mg.

In Europe and in Canada, the total pharmacy costs and use of rescue medications reported were lower for patients receiving prophylaxis with palonosetron.

Cannabinoids (nabilone, tetra-hydrocannabinol), although promising in the control of chemotherapy-induced sickness, are not effective for PONV.

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